Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) Sensitizes LNCaP Prostate Cancer Cells to TRAIL-Induced Apoptosis
Int J Oncol, 2012 Jun 25
Naturally occurring phenolic compounds have been shown to sensitize prostate cancer cells to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. TRAIL is a potent stimulator of apoptosis in cancer cells and an important immune effector molecule in the surveillance and elimination of developing tumours. However, many cancer cells are resistant to TRAIL-mediated death. In this study, we aimed to determine the mechanisms by which TRAIL resistance can be overcome in prostate cancer cells by...