Wound Repair Activity of Acacia, Buckwheat and Manuka Honeys Examined

(Apitherapy News - 8/17/12)

Epithelial Mesenchymal Transition Traits in Honey-Driven Keratinocyte Wound Healing: Comparison Among Different Honeys 

Wound Repair And Regeneration by Elia Ranzato PhD, Simona Martinotti PhD, Bruno Burlando PhD

Wound Repair Regen, 2012 Aug 10 Honey has been used since ancient times for wound repair, but the subjacent mechanisms are almost unknown. We have tried to elucidate the modulatory role of honey in an in vitro model of HaCaT keratinocyte re-epithelialization by using acacia, buckwheat, and manuka honeys. Scratch wound and...



Propolis Component Boosts Prostate Cancer Cell Deaths

Authors: Ewelina Szliszka, Grzegorz Zydowicz, Elzbieta Mizgala, Wojciech Krol (Apitherapy News & International Journal of Oncology) July 4, 2012

Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) Sensitizes LNCaP Prostate Cancer Cells to TRAIL-Induced Apoptosis

Int J Oncol, 2012 Jun 25


Naturally occurring phenolic compounds have been shown to sensitize prostate cancer cells to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. TRAIL is a potent stimulator of apoptosis in cancer cells and an important immune effector molecule in the surveillance and elimination of developing tumours. However, many cancer cells are resistant to TRAIL-mediated death. In this study, we aimed to determine the mechanisms by which TRAIL resistance can be overcome in prostate cancer cells by...


Ground Honey Bee Larvae has Health Benefits

By Lady Spirit Moon June 29, 2012  (Walter T. Kelley Co./Apitherapy: Apilarnil July 5, 2012)  

Apilarnil is an acronym: 
■ Api – bee 
■ lar for larvae 
■ n for Nicolae, the first name of the man who discovered Apilarnil, and 
■ il the two initials for the discoverer’s last name, Iliesiu.

About 30 years ago in Romania, Nicolae discovered when he fed his chickens and ducks dead bees, the weak ones not only got stronger, but the birds grew faster than normal. Apilarnil is the white, almost fully formed, drone larvae. When ground, strained through special filters, and added to bee pollen, Apilarnil has compositions similar to and is administered like Royal Jelly. It is anti-viral as Royal Jelly. It’s high in nutrients for memory, and is good for male sexuality and gastro-intestinal use. Often it is administered in powder or tablet form.

Like many bee products, Apilarnil’s medicinal properties are undergoing constant research and discovery. These are amazing insects!


(From Kelley's Bees Editor’s Note: Lady Spirit Moon is an ambassador for the Center for Honeybee Research,www.chbr.org. We featured the Center a few issues ago, and are making it easier for our readers to help the Center help honeybees by clicking here. The Walter T. Kelley Company will donate a dollar for every contribution our readers make. Thank you!)

Scientists Discover Bees Can "turn back time," Reverse Brain Aging

(Phys.org) -- Scientists at Arizona State University have discovered that older honey bees effectively reverse brain aging when they take on nest responsibilities typically handled by much younger bees. While current research on human age-related dementia focuses on potential new drug treatments, researchers say these findings suggest that social interventions may be used to slow or treat age-related dementia.

In a study published in the scientific journal Experimental Gerontology, a team of scientists from ASU and the Norwegian University of Life Sciences, led by Gro Amdam, an associate professor in ASU’s School of , presented findings that show that tricking older, foraging  into doing social tasks inside the nest causes changes in the molecular structure of their brains.


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Bees Shed Light on Human Sweet Perception & Metabolic Disorders

Researchers identify connection between sugar sensitivity, diabetic physiology and metabolism      (The following is brought to us by the American Bee Journal  July 2, 2012)

TEMPE, Ariz. – Scientists at Arizona State University have discovered that honey bees may teach us about basic connections between taste perception and metabolic disorders in humans. By experimenting with honey bee genetics, researchers have identified connections between sugar sensitivity, diabetic physiology and carbohydrate metabolism. Bees and humans may partially share these connections.

In a study published in the open-access journal PLoS Genetics (Public Library of Science), Gro Amdam, an associate professor, and Ying Wang, a research scientist, in the School of Life Sciences in ASU's College of Liberal Arts and Sciences, explain how for the first time, they've successfully inactivated two genes in the bees' "master regulator" module that controls food-related behaviors. By doing so, researchers discovered a possible molecular link between sweet taste perception and the state of internal energy.

"A bee's sensitivity to sugar reveals her attitude towards food, how old the bee is when she starts searching for nectar and pollen, and which kind of food she prefers to collect," said Wang, lead author of the paper. "By suppressing these two 'master' genes, we discovered that bees can become more sensitive to sweet taste. But interestingly, those bees also had very high blood sugar levels, and low levels of insulin, much like people who have Type 1 diabetes."

In Amdam's honey bee lab at ASU, scientists suppressed two genes including vitellogenin, which is similar to a human gene called apolipoprotein B, and ultraspiracle, which partners with an insect hormone that has some functions in common with the human thyroid hormone. The team is the first in the world to accomplish this double gene-suppressing technique. Researchers used this method to understand how the master regulator works.

"Now, if one can use the bees to understand how taste perception and metabolic syndromes are connected, it's a very useful tool," said Amdam, who also has a honey bee laboratory at the Norwegian University of Life Sciences. "Most of what we know about deficits in human perceptions is from people who are very sick or have had a brain trauma. We know shockingly little about people in this area."

The researchers are now considering how, exactly, the bees' sweet taste was enhanced by the experiment. The most metabolically active tissue of the bee, called the fat body, may hold the key. The fat body is similar to the liver and abdominal fat in humans, in that it helps store nutrients and create energy.

Amdam explains that taste perception evolved as a survival mechanism, for bees as well as for people. For example, bitter foods may be poisonous or sweet taste may signal foods rich in calories for energy. For all animals, taste perception must communicate properly with one's internal energetic state to control food intake and maintain normal life functions. Without this, poorly functioning taste perception can contribute to unhealthy eating behaviors and metabolic diseases such as diabetes and obesity.

"From this study, we realized we can take advantage of honey bees in understanding how food-related behaviors interact with internal metabolism, as well as how to manipulate these food-related behaviors in order to control metabolic disorders," added Amdam.  

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Related articles:



Honey bees may help scientists understand how food-related behaviors interact with internal metabolism and how to manipulate those behaviors to control metabolic disorders.

(Photo by Christofer Bang)





Patients all A Buzz about Bee Venom Treatment

Tara Cleary, Reuters   (Apatherapy News)  June 24, 2012
A bee farmer in the Philippines uses sting therapy to treat patients with gout, arthritis, and autoimmune disorders.
Feeling the pain of a bee sting, but this sting is deliberate. Filipino bee farmer turned alternative medicine practitioner, Joel Magsaysay is performing bee venom therapy at his farm outside Manila. He's hoping the sting will start healing his patients damaged nerves, just like it healed him after a stroke that left the right side of his body paralyzed 12 years ago. He says proteins found in bee venom awakened the nerves in his torso and limbs and restored his muscle movement…

The Blessing of the Bees

From NYC Beekeeping

We're buzzing with excitement...the first-ever blessing of the bees took place earlier today at Cathedral St John the Divine with  NYCBeekeeping.org!

In the photo: the Bishop and Jim and Nicole (the beekeeper at the Cathedral) from NYCBeekeeping.org. 
Photo © by Jan Mun

By the way, if you're in New York on June 25th catch the Booktalk & Summer Gathering: Kim Flottum - "The Buzz about Bees and the Future of Food" at The Arsenal in Central Park.

Of Honeybees and World Food Supply

By: Georginna Pfost (Christian Science Monitor-A Christian Science Perspective) June 19, 2012

Pollinators, including bees, butterflies, and moths, as well as bats and birds, are a critical part of our planet’s ecosystem – the interconnected structure of life. In fact, one-third of humans’ food comes from insect-pollinated plants. In the process of collecting pollen and nectar to sustain themselves, pollinators help plants reproduce by spreading their pollen. And, in turn, the plants’ fruits and seeds provide food for other animals and people.

Consequently, many people (particularly backyard beekeepers like me) are celebrating the sixth annualPollinator Week (June 18-24) by doing such things as planting more varieties of flowers, buying more organically grown food, and eliminating the use of pesticides in our gardens. These actions help feed pollinators and prevent harm to them. But given recent news of spring honeybee die-offs in the Midwestern United States (apparently related to the sowing of pesticide-coated corn), I’m also taking time to specifically pray for these small creatures. 


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Diggin' It

Pollination power in the garden


Buckwheat Honey Protects Against DNA Damage

Apitherapy News  June 18, 2012

Protective Effects of Buckwheat Honey on DNA Damage Induced by Hydroxyl Radicals Food Chem Toxicol, 2012 Jun 6 To understand the antioxidant properties of buckwheat honeys, we investigated their antioxidant effects on hydroxyl radical-induced DNA breaks in the non-site-specific and site-specific systems, the physicochemical properties, antioxidant activities (1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical scavenging activity, chelating, and reducing power assays), total phenolic content and individual phenolic acids were also determined.


New Methods to Reduce Allergens in Propolis

Apitherapy News (June 15, 2012)

Biotransformation Strategy to Reduce Allergens in Propolis Appl. Environ. Microbiol, July 2012 vol. 78 no. 13 4654-4658Propolis (bee glue) is a resinous, sticky, dark-colored material produced by honeybees. Propolis today, due to its medicinal properties, is increasingly popular and is extensively used in food, beverages, and cosmetic products.Besides its numerous positive properties, propolis may also have adverse effects, such as, principally, allergic eczematous contact dermatitis in apiarists and in consumers with an allergic predisposition. Read more...

UCD Worker Wins Award for Rare Photo of Bee Sting in Action

By Andrea Gallo (Sacramento Bee) June 14, 2012 

A rare photograph of a honeybee stinging a man, with its abdominal tissue trailing behind, was more than 100 years in the making.

UC Davis communications specialist Kathy Keatley Garvey in the Department of Entomology said she has taken at least 1 million photos of honeybees in her lifetime, but this snapshot won the first-place gold feature photo award in an Association for Communication Excellence competition. The international organization includes communicators, educators and information technologists.

Garvey has bees in her blood: As dairy farmers,her father and grandfather kept bees to pollinate their orchards. She said bees have been in her family since around 1850. Read more...

Also see the UC Davis Apiculture Newsletter (Mar-Apr 2012)

Practical Method Developed to Access Royal Jelly Freshness

Huo-Qing Zheng, Wen-Ting Wei, Lli-Ming Wu, Fu-Liang Hu, Vincent Dietemann (Journal of Food Science) June 4, 2012

Fast Determination of Royal Jelly Freshness by a Chromogenic Reaction

Royal jelly is one of the most important products of honeybees. Given its role in development of bee brood into fertile individuals of the royal caste it is also used in health products for human consumption. Royal jelly spoils and loses its health-promoting properties depending on storage duration and conditions. To ensure product quality before selling, it is therefore necessary to assess royal jelly freshness. Many indexes of freshness have been suggested, but they all lack reliability or require complex and time-consuming analyses. Here we describe a method to detect royal jelly freshness based on a chromogenic reaction between royal jelly and HCl. We demonstrate that analyses based on color parameters allow for the discrimination of royal jelly samples based on the duration of their storage. Color parameters of royal jelly stored at −18 and 4 °C for 28 d remained comparable to that of fresh samples, which supports the reliability of the method. The method of freshness determination described is practical, cheap, and fast and can thus be used in real-time when trading royal jelly.

The method developed can be used to assess royal jelly freshness. It is practical, cheap, and fast and can thus be used in real-time when trading royal jelly.


Beyond Pesticides Forum

The 30th National Pesticide Forum was held on March 30-31, 2012 at Yale University. 

You can read about the forum and view videos at: http://www.beyondpesticides.org/pollinators/index.htm#video

Some of the topics include:

Poisoning of the Bees (Dave Hackenberg, beekeeper)

Neonicotinoid Pesticides and Bees, substitute lecture (Christian Krupke, PhD with Greg Hunt, Purdue University)

Protecting Pollinators: Beekeeping and beyond (Workshop)

To view more videos from the forum:http://www.youtube.com/playlist?list=PL762B9D6032F815D6&feature=plcp


Bee Venom Acupuncture Helps Treat Parkinson's Disease

Apitherapy News  May 31, 2012

This study aimed to explore the effectiveness of both acupuncture and bee venom acupuncture as adjuvant therapies for idiopathic Parkinson's disease.We recruited 43 adults with idiopathic Parkinson's disease who had been on a stable dose of antiparkinsonian medication for at least 1 month. They were randomly assigned to 1 of 3 groups: acupuncture, bee venom acupuncture, or control. All participants were assessed using the Unified Parkinson's Disease Rating Scale, the Parkinson's Disease Quality of Life Questionnaire, the Beck Depression Inventory, the Berg Balance Scale, and the time and number of steps required to walk 30 m. Treatment groups underwent stimulation of 10 acupuncture points using acupuncture or bee venom acupuncture twice a week for 8 weeks. The initial assessment was repeated at the completion of treatment. The control group did not receive any treatment.  Read more...

ScienceDirect.com   May 24, 2012

Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease


This study aimed to explore the effectiveness of both acupuncture and bee venom acupuncture as adjuvant therapies for idiopathic Parkinson's disease. Read more: 

Missouri Woman says Bee Venom Therapy Helped Treat MS

Apitherapy News  June 1, 2012

A Woman on the Move, A Woman of Courage

One of the first things Farrell learned about MS is that it doesn’t typically affect the longevity of your life, but it will affect your quality.With no traditional treatment known for her form of MS, Farrell turned to alternative treatments, including bee venom injections or “stings,” which she did from 1997 to 2009.

“I had 15 stings every other day,” said Farrell. “It was very painful.”She had heard of the treatment on an episode of the TV show “Unsolved Mysteries.” Read more...

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Honey May Help Protect Organs During Inflammatory Diseases

(Apitherapy News) May 27, 2012

Gelam Honey Has a Protective Effect against Lipopolysaccharide (LPS)-Induced Organ Failure Int. J. Mol. Sci, 2012, 13(5), 6370-6381

Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effects in reducing infections and healing wounds.The aim of this study was to investigate the effects of intravenously-injected Gelam honey in protecting organs from lethal doses of lipopolysaccharide (LPS). Read more: http://apitherapy.blogspot.com/

Allergic Patients Should Be Advised of Anaphylaxis from Bee Pollen

Quantum Day (May 22, 2012)

Bee pollen are pollen granules collected and processed by bees. 

It is collected from flowers during pollination. The pollen contains small amounts of minerals and vitamins and is very high in protein and carbohydrates.

The pollen is made by worker honeybees who pack the collected pollen into granules (pollen balls) with added honey or nectar. The pollen is also mixed with enzymes, fungi and bacteria. This results in pollen that is higher in nutrition than untreated pollen and is the primary source of protein for the hive.

The average composition of bee pollen is said to be 55% carbohydrates, 35% proteins, 3% minerals and vitamins, 2% fatty acids, and 5% of diverse other components.

Bee pollen supplements can cause anaphylactic reactions

Although many people take bee pollen as a health supplement, it can cause severe anaphylactic reactions. However, most people are unaware of the risks, states an article published in CMAJ (Canadian Medical Association Journal).

Read more: http://www.quantumday.com/

Click to find out more about Bee Pollen (video):

Photos from Quantum

Bee Pollen Supplements Can Cause Anaphlylactic Reactions

From: The American Bee Journal Extra  May 22, 2012

Although many people take bee pollen as a health supplement, it can cause severe anaphylactic reactions. However, most people are unaware of the risks, states an article published in CMAJ (Canadian Medical Association Journal).

A case study in the journal illuminates the possible hazards of ingesting bee pollen. A 30-year-old woman with seasonal allergies but no history of allergies to food, drugs, insects or latex had an anaphylactic reaction after taking bee pollen. She had swelling of the eyelids, lips and throat, difficulty swallowing, hives and other life-threatening symptoms. After emergency treatment and discontinuation of the bee pollen supplements, there were no further reactions.

"Anaphylaxis associated with the consumption of bee pollen has been reported in the literature, but many people remain unaware of this potential hazard," write Dr. Amanda Jagdis, University of British Columbia, and Dr. Gordon Sussman, St. Michael's Hospital and the University of Toronto.

Anaphylactic reactions after ingesting bee pollen have been reported in people with no history of allergies or only seasonal allergies. In a Greek study in which atopic participants underwent skin tests for reactions to bee pollen, 73% (of 145 patients) had positive skin test reactions to one or more types of bee pollen extracts.

"Health care providers should be aware of the potential for reaction, and patients with pollen allergy should be advised of the potential risk when consuming these products — it is not known who will have an allergic reaction upon ingesting bee pollen," conclude the authors.

(The above posted with permission from the American Bee Journal.) 

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